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Home Lifestyle Health

Is Covid vaccination programmes going to a hopeless end?

Shehin by Shehin
October 16, 2020
in Health
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Is Covid vaccination programmes going to a hopeless end?
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A couple of months ago, the world was hopefully watching several prominent vaccination programmes against Covid-19 spread that included UAE. Even the Russian government declared their vaccination release, which was later disapproved by the WHO. But, the question is, what became of the vaccination trials as of now? Why was two leading vaccination programmes suspended? Where is the hope of vaccination now?

Why vaccination ventures were halted?

Pharmaceutical company Johnson & Johnson announced on Monday that it had suspended human trials of its coronavirus vaccine because of the “unexplained illness” of a participant. The Phase 3 trials were set up to assess the effectiveness and safety of the vaccine in humans and were expected to involve 60,000 participants in the US and elsewhere.

The following day, Eli Lilly said it was pausing its Phase 3 trial involving the anti-viral remdesivir and another drug. The action was reportedly taken out of “an abundance of caution” following a “potential safety concern”. As with the Johnson & Johnson trial, the precise details are unclear – as is the date when, if ever, the 10,000-participant trial will restart.

In September, trials of a corona virus vaccine created by scientists at the University of Oxford and tested by AstraZeneca were halted after a participant developed an unexplained illness. It emerged that a healthy 37-year-old woman developed transverse myelitis, causing inflammation of the spine – an extremely rare but recognized reaction to vaccination. The huge international study restarted in mid-September, although it is still on hold in the US.

How dangerous is this?

Without the knowledge of the proper cause of the incidents, it is impossible to cite the danger. But it is likely that the incidents are demonstrations of a basic law of probability: that even extremely rare events will occur if given the opportunity.

These trials involved tens of thousands of patients, raising the chances of at least a few rare side-effects being seen. Ironically, the fact that the trials have been halted is seen by clinical experts as proof that the testing methodology is working as it should, detecting even hints of potential problems and investigating them thoroughly before restarting the trials.

Trusting the drug companies

The share prices of Johnson & Johnson and Eli Lilly dipped a few per cent following the announcement, and they want the trials resumed as soon as possible. But the decision to do so is not in their hands.

Clinical trials are overseen by independent Data and Safety Monitoring Boards (DSMBs) whose decisions are made in meetings that exclude researchers and company officials. The decision to pause the Johnson & Johnson and Eli Lilly trials were made by their independent boards.

Will the trials get abandoned?

May be; or most probably, yes. The Eli Lilly trial involves a combination of drugs that has been used with few patients. The two components of the treatment – the anti-viral remdesivir and a so-called monoclonal antibody – are both at the cutting edge of scientific research. The Johnson & Johnson vaccine uses a modified human cold virus to trigger immunity, but it has been used for other diseases. Even so, around one in six vaccines reaching the same stage of development fail.

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